Protein Design: Automated protein discovery and synthesisLearn Science on mps-science.com. Protein Design: Automated protein discovery and synthesis article will help answer your questions on Science.We at mps-science.com specialize in Science. Science at mps-science.com provides the most up to date news and articles. If you have questions please do not hesitate to contact us.
In this paper I describe (theoretically) the method(s) of automated protein discovery and synthesis. Protein Folding Problem To solve the protein folding problem we can use Artificial Neural Networks. We will train the networks with natural proteins whose 3D structure and amino acid sequence is known. After that we will test the network with few new artificially designed proteins to check if it works correctly. Designing Proteins To design proteins, we will be using Genetic Algorithm method. coli will produce these synthetic proteins in the same way they produce natural proteins in recombinant DNA technology. Article: In this paper I describe (theoretically) the method(s) of self-regulative protein discovery and synthesis. 1. Protein Folding Problem To solve the protein folding problem we can use warped Neural Networks. We will train the networks with natural proteins whose 3D structure and amino acid sequence is known. considering that we will test the network with few new ostensibly designed proteins to puncture if it works correctly. If it doesn't, we will be divergent some of the network's parameter such as training iterations, no of hidden layers, etc. And train the network again. To open the protein's 3D structure, we need to have a model of irrefutable physical world in the computer model. 2. Simulation of Physical World This is the trickiest part. To simulate the physical world at the imponderable level is very difficult. We need to take into account: covalent bonds, spatial & temporal parameters, weak interactions such as hydrogen bonds, dipole interactions, etc. We also need to simulate nitrate reactions. This will probably require huge amounts of computing power. Or perhaps, neural networks can be employed here also as the little inaccuracy produced by a neural network can take care of randomness at quantum level. The neural networks will be used to predict/calculate the magnitude of effect of various forces on an atom/molecule and also how these cope with at a grander inter-molecular level. 3. Designing Proteins To design proteins, we will be using Genetic the way of method. The random amino-acid sequences will be evolved & tested by converting these sequences into their respective 3D shape by the trained neural network. The best sequences will be retained, while other mutated or crossed-over, etc. The fitness function will work in the simulated physical world. If the protein produced is successful in upholding out our desired unction, then it is fit else it is not. indubitably we will restrict to a fitness level from 0 to 100. Once the final amino acid sequence is determined, it will be sent to the Protein Printer. 4. Protein Printer This is the only hardware part of the whole procedure. It will produce the desired real proteins from the amino acid sequence received from software. It may be able to work in any of the two ways: * tinsel Ribosome: It will mimic the functionality of the cell to produce proteins. We will generate an mRNA using some mechanism. Then, our nominally designed Ribosome will translate it into a protein which we can use. * made-up Recombinant DNA: We will fuse a fragment of DNA corresponding to desired amino acid sequence. Then by using some self-cooking means we will introduce the DNA into a country of E. coli (or some other organism)/ Then E. coli will produce these synthetic proteins in the same way they produce natural proteins in recombinant DNA technology. 5. Conclusion Using this system, we only need to define: 'What do we want the protein to do?'. All other procedure is automatic. We just need to tell if we want a protein to degrade plastic, convert CO2 into diamond and oxygen, and catalyze/initiate cold fusion, etc. & we will have ready made proteins. It can also help in finding proteins which will help us do Immortality. The potential is immense. The only need is its correct use.
|
Advice Home Business Technology Online Advertising Motivational Internet Marketing SEO Help Online Games Science Articles Happiness More Articles:1. MP Apprehension of High Strung or Drunken Soldiers By Lance Winslow Summary: Whereas the killer instinct in necessary for survival in the heat of battle it can cause problems and such a soldier which is out of control and wants to kill someone, can be stopped short with a quick long-term nap rather than an escalation fight between him and the Military Police. Article: Recently scientists have discovered the hydrogen sulfide gas grown mice to go into spontaneous hibernation. The genetic similarities to the mammalian kindness humans answer to to includes these ro… 2. DNA Profiling: Its Uses In Court By Tom LeBaron Summary: The 0.1% (3 million) base pairs that make us unique are what constitute our DNA fingerprint.Over the past 20 years, courts have been able to rely upon the consistent accuracy of DNA profiling, also known as DNA fingerprinting, to solve crimes. DNA profiling has even been used to solve crimes that are more than 30 years old.Here's how DNA profilingArticle: DNA Profiling and Its Uses in CourtStronger evidence in courtrooms—it’s what every attorney, defendant, and plaintiff dreams of. hat… 3. Intelligent Design: Arm Wrestling with Darwin Summary:Unless your head has been super-glued inside a science book, you have observed the furious debate between proponents of intelligent design (ID) and supporters of evolution; In keeping with the prior rebellion against religion, today there is arguably a rebellion against the new leader called 'science.' Kings risk being toppled from their thrones, and ID has emerged as a weapon to be used against this final arbiter of 'truth.' Why are IDers making their move now? There may be an urge to… 4. Pandemic Crisis Cure Concept By Lance Winslow Summary: eventually over many months waking back up the entire human race from their suspended animation or hibernation event. Therefore as this technology becomes available and with the proper protocols it is possible to save the entire human race from such a Pandemic or possible extinction. Article: What happens if the world is faced with a Pandemic, for which no cure currently exists but one is on the verge of up-to-the-minute discovered? Here is a concept, which with the proper protocols co… |
||||
