Protein Design: Automated protein discovery and synthesisLearn Science on mps-science.com. Protein Design: Automated protein discovery and synthesis article will help answer your questions on Science.We at mps-science.com specialize in Science. Science at mps-science.com provides the most up to date news and articles. If you have questions please do not hesitate to contact us.
In this paper I describe (theoretically) the method(s) of automated protein discovery and synthesis. Protein Folding Problem To solve the protein folding problem we can use Artificial Neural Networks. We will train the networks with natural proteins whose 3D structure and amino acid sequence is known. After that we will test the network with few new artificially designed proteins to check if it works correctly. Designing Proteins To design proteins, we will be using Genetic Algorithm method. coli will produce these synthetic proteins in the same way they produce natural proteins in recombinant DNA technology. Article: In this paper I describe (theoretically) the method(s) of self-regulative protein discovery and synthesis. 1. Protein Folding Problem To solve the protein folding problem we can use warped Neural Networks. We will train the networks with natural proteins whose 3D structure and amino acid sequence is known. considering that we will test the network with few new ostensibly designed proteins to puncture if it works correctly. If it doesn't, we will be divergent some of the network's parameter such as training iterations, no of hidden layers, etc. And train the network again. To open the protein's 3D structure, we need to have a model of irrefutable physical world in the computer model. 2. Simulation of Physical World This is the trickiest part. To simulate the physical world at the imponderable level is very difficult. We need to take into account: covalent bonds, spatial & temporal parameters, weak interactions such as hydrogen bonds, dipole interactions, etc. We also need to simulate nitrate reactions. This will probably require huge amounts of computing power. Or perhaps, neural networks can be employed here also as the little inaccuracy produced by a neural network can take care of randomness at quantum level. The neural networks will be used to predict/calculate the magnitude of effect of various forces on an atom/molecule and also how these cope with at a grander inter-molecular level. 3. Designing Proteins To design proteins, we will be using Genetic the way of method. The random amino-acid sequences will be evolved & tested by converting these sequences into their respective 3D shape by the trained neural network. The best sequences will be retained, while other mutated or crossed-over, etc. The fitness function will work in the simulated physical world. If the protein produced is successful in upholding out our desired unction, then it is fit else it is not. indubitably we will restrict to a fitness level from 0 to 100. Once the final amino acid sequence is determined, it will be sent to the Protein Printer. 4. Protein Printer This is the only hardware part of the whole procedure. It will produce the desired real proteins from the amino acid sequence received from software. It may be able to work in any of the two ways: * tinsel Ribosome: It will mimic the functionality of the cell to produce proteins. We will generate an mRNA using some mechanism. Then, our nominally designed Ribosome will translate it into a protein which we can use. * made-up Recombinant DNA: We will fuse a fragment of DNA corresponding to desired amino acid sequence. Then by using some self-cooking means we will introduce the DNA into a country of E. coli (or some other organism)/ Then E. coli will produce these synthetic proteins in the same way they produce natural proteins in recombinant DNA technology. 5. Conclusion Using this system, we only need to define: 'What do we want the protein to do?'. All other procedure is automatic. We just need to tell if we want a protein to degrade plastic, convert CO2 into diamond and oxygen, and catalyze/initiate cold fusion, etc. & we will have ready made proteins. It can also help in finding proteins which will help us do Immortality. The potential is immense. The only need is its correct use.
|
Advice Home Business Technology Online Advertising Motivational Internet Marketing SEO Help Online Games Science Articles Happiness More Articles:1. Efficient Transportation Systems By Lance Winslow Summary: When large items need to travel down existing roadways and are considered wide loads, long loads or oversized loads they often have different rules for different states, highways, federal and even some counties have their own rules. When businesses have to deal with all these different, often redundant rules and regulations they cannot use the existing transportatioArticle: We see in the organized world of the Japanese with their transit systems and floating airports and super engineer… 2. The Characteristics of Soul Summary:At the dawn of spring, I am reminded by my children the joy of anticipating new life. They will usually see a flower or two that has made its way through the soil to a world beyond itself. Like a flower, you begin to radiate your own soul from the essence of your own being. Each spring, take the time to notice the part of you opening up to new life. The growth that follows is created from what we attend to or hold our attention on within us. Like the pedals of a flower opening to the wor… 3. Pump It Up! Summary:Pumps are pump in anyway you put it. These pumps still work the same way as other pumps, the only difference is that instead of manually doing all the pumping, a motor is hooked up into the pump to make the pumping faster and at a steadier phase. But this time, instead of just pumping out water to an outgoing line they have a specialized central pump that pumps the water back into the city's water treatment facility to cure the water and the water waste. So the list goes on and on for … 4. Thought Control Summary: Think of anything that gets your heart racing and the TV would turn on, right? Call it mind power, thought control or whatever. We are a long way from that, but we are right at the brink of building machines that give us thought control of the things around us. You see, even with the crude measurements being done now, as long as we can choose what to think about, and any resulting change in the brain can be measured, the possibilities are endless. Article:Thought control? How would you … |
||||
