Protein Design: Automated protein discovery and synthesisLearn Science on mps-science.com. Protein Design: Automated protein discovery and synthesis article will help answer your questions on Science.We at mps-science.com specialize in Science. Science at mps-science.com provides the most up to date news and articles. If you have questions please do not hesitate to contact us.
In this paper I describe (theoretically) the method(s) of automated protein discovery and synthesis. Protein Folding Problem To solve the protein folding problem we can use Artificial Neural Networks. We will train the networks with natural proteins whose 3D structure and amino acid sequence is known. After that we will test the network with few new artificially designed proteins to check if it works correctly. Designing Proteins To design proteins, we will be using Genetic Algorithm method. coli will produce these synthetic proteins in the same way they produce natural proteins in recombinant DNA technology. Article: In this paper I describe (theoretically) the method(s) of self-regulative protein discovery and synthesis. 1. Protein Folding Problem To solve the protein folding problem we can use warped Neural Networks. We will train the networks with natural proteins whose 3D structure and amino acid sequence is known. considering that we will test the network with few new ostensibly designed proteins to puncture if it works correctly. If it doesn't, we will be divergent some of the network's parameter such as training iterations, no of hidden layers, etc. And train the network again. To open the protein's 3D structure, we need to have a model of irrefutable physical world in the computer model. 2. Simulation of Physical World This is the trickiest part. To simulate the physical world at the imponderable level is very difficult. We need to take into account: covalent bonds, spatial & temporal parameters, weak interactions such as hydrogen bonds, dipole interactions, etc. We also need to simulate nitrate reactions. This will probably require huge amounts of computing power. Or perhaps, neural networks can be employed here also as the little inaccuracy produced by a neural network can take care of randomness at quantum level. The neural networks will be used to predict/calculate the magnitude of effect of various forces on an atom/molecule and also how these cope with at a grander inter-molecular level. 3. Designing Proteins To design proteins, we will be using Genetic the way of method. The random amino-acid sequences will be evolved & tested by converting these sequences into their respective 3D shape by the trained neural network. The best sequences will be retained, while other mutated or crossed-over, etc. The fitness function will work in the simulated physical world. If the protein produced is successful in upholding out our desired unction, then it is fit else it is not. indubitably we will restrict to a fitness level from 0 to 100. Once the final amino acid sequence is determined, it will be sent to the Protein Printer. 4. Protein Printer This is the only hardware part of the whole procedure. It will produce the desired real proteins from the amino acid sequence received from software. It may be able to work in any of the two ways: * tinsel Ribosome: It will mimic the functionality of the cell to produce proteins. We will generate an mRNA using some mechanism. Then, our nominally designed Ribosome will translate it into a protein which we can use. * made-up Recombinant DNA: We will fuse a fragment of DNA corresponding to desired amino acid sequence. Then by using some self-cooking means we will introduce the DNA into a country of E. coli (or some other organism)/ Then E. coli will produce these synthetic proteins in the same way they produce natural proteins in recombinant DNA technology. 5. Conclusion Using this system, we only need to define: 'What do we want the protein to do?'. All other procedure is automatic. We just need to tell if we want a protein to degrade plastic, convert CO2 into diamond and oxygen, and catalyze/initiate cold fusion, etc. & we will have ready made proteins. It can also help in finding proteins which will help us do Immortality. The potential is immense. The only need is its correct use.
|
Advice Home Business Technology Online Advertising Motivational Internet Marketing SEO Help Online Games Science Articles Happiness More Articles:1. How To Make Lighter and Thinner Magnesium Components? Summary: While the current warm forming press systems are complicated to operate as they require the preliminary building of stroke and force profiles for the specific products using data acquisition modules and forming simulation softwares, the increased replacement of aluminum and plastics with magnesium for handheld electronic devices may well accelerate this process. Article:Magnesium is the lightest structural material offering very good damping characteristics, weldability and excellent s… 2. Magnetic Propulsion for GI Joe? By Lance Winslow Summary: If the rings which travel around have steel re-enforcement you can build a third ring which is attracted or repelled from the outer two rings as they spin and the magnets on the third ring flip over as you choose any direction to travel or turn to.Also assisting in the isolating of the inherent instability of the craft at slow speeds of climb and lifting whenArticle: Thought of the day. I talked to an old guy who gave me this idea, he wanted to create a magnet propelled anti-gravity an… 3. Why Venus Flytraps Make Lousy Science Fair Projects Summary:Every year, I receive many phone calls from parents wanting to purchase Venus Flytraps for their kids' science project. During dormancy, Flytraps stop growing and their traps stop working. For any science projects to work, your young budding scientists will need to use plants that are actively growing. Traps will live for about 2 months, then it stops working and slowly turns black, regardless if it had been triggered or not. Again, if a trap does not close properly, would it be because … 4. Science in College By Simon Hall Summary: With science courses in Universities and Colleges in Ireland varying with the same degree as types of beetle, it is a veritable mix match of scientific disciplines. level, science is not broken into it's respective fields but taught as a modular subject.The final three years of secondary school are dedicated to study for the Leaving Certificate. Article: With science courses in Universities and Colleges in Ireland varying with the same degree as types of beetle, it is a veritable mix … |
||||
