Protein Design: Automated protein discovery and synthesisLearn Science on mps-science.com. Protein Design: Automated protein discovery and synthesis article will help answer your questions on Science.We at mps-science.com specialize in Science. Science at mps-science.com provides the most up to date news and articles. If you have questions please do not hesitate to contact us.
In this paper I describe (theoretically) the method(s) of automated protein discovery and synthesis. Protein Folding Problem To solve the protein folding problem we can use Artificial Neural Networks. We will train the networks with natural proteins whose 3D structure and amino acid sequence is known. After that we will test the network with few new artificially designed proteins to check if it works correctly. Designing Proteins To design proteins, we will be using Genetic Algorithm method. coli will produce these synthetic proteins in the same way they produce natural proteins in recombinant DNA technology. Article: In this paper I describe (theoretically) the method(s) of self-regulative protein discovery and synthesis. 1. Protein Folding Problem To solve the protein folding problem we can use warped Neural Networks. We will train the networks with natural proteins whose 3D structure and amino acid sequence is known. considering that we will test the network with few new ostensibly designed proteins to puncture if it works correctly. If it doesn't, we will be divergent some of the network's parameter such as training iterations, no of hidden layers, etc. And train the network again. To open the protein's 3D structure, we need to have a model of irrefutable physical world in the computer model. 2. Simulation of Physical World This is the trickiest part. To simulate the physical world at the imponderable level is very difficult. We need to take into account: covalent bonds, spatial & temporal parameters, weak interactions such as hydrogen bonds, dipole interactions, etc. We also need to simulate nitrate reactions. This will probably require huge amounts of computing power. Or perhaps, neural networks can be employed here also as the little inaccuracy produced by a neural network can take care of randomness at quantum level. The neural networks will be used to predict/calculate the magnitude of effect of various forces on an atom/molecule and also how these cope with at a grander inter-molecular level. 3. Designing Proteins To design proteins, we will be using Genetic the way of method. The random amino-acid sequences will be evolved & tested by converting these sequences into their respective 3D shape by the trained neural network. The best sequences will be retained, while other mutated or crossed-over, etc. The fitness function will work in the simulated physical world. If the protein produced is successful in upholding out our desired unction, then it is fit else it is not. indubitably we will restrict to a fitness level from 0 to 100. Once the final amino acid sequence is determined, it will be sent to the Protein Printer. 4. Protein Printer This is the only hardware part of the whole procedure. It will produce the desired real proteins from the amino acid sequence received from software. It may be able to work in any of the two ways: * tinsel Ribosome: It will mimic the functionality of the cell to produce proteins. We will generate an mRNA using some mechanism. Then, our nominally designed Ribosome will translate it into a protein which we can use. * made-up Recombinant DNA: We will fuse a fragment of DNA corresponding to desired amino acid sequence. Then by using some self-cooking means we will introduce the DNA into a country of E. coli (or some other organism)/ Then E. coli will produce these synthetic proteins in the same way they produce natural proteins in recombinant DNA technology. 5. Conclusion Using this system, we only need to define: 'What do we want the protein to do?'. All other procedure is automatic. We just need to tell if we want a protein to degrade plastic, convert CO2 into diamond and oxygen, and catalyze/initiate cold fusion, etc. & we will have ready made proteins. It can also help in finding proteins which will help us do Immortality. The potential is immense. The only need is its correct use.
|
Advice Home Business Technology Online Advertising Motivational Internet Marketing SEO Help Online Games Science Articles Happiness More Articles:1. Einstein Half Dead By Vincent Wilmot Summary: 100 years ago Albert Einstein developed his Relativity Theory of physics that claimed that the universe is actually based on a space-time-gravity continuum (a non-mechanical version of Rene Descartes' earlier mechanical ether theory) and with time as variable and relative.Einstein believed that his theory disproved "all of Isaac Newton's physics theory", Article: 100 years ago Albert Einstein developed his Relativity Theory of physics that specious that the universe is actually based … 2. Brain Waves Activating to the Tune of a Different Drummer? By Lance Winslow Summary: Could such an induced simulation cause this additional potential peak for higher learning?We know rogue waves appear in ocean waves, light waves, sound waves and we have theories of gravity and time that this occurs which could indicate anomalies of a very interesting nature for many purposes such as anti-gravity travel, time travel, creation of time gates, mArticle: Well, here is a most interesting thought. There are many who have heart murmurs from bloodline and many with heart murmu… 3. Crystalline Diamond Summary:A Diamond is a crystalline form of carbon. These synthetic diamonds are typically classified with poor-quality specimens and as a result are suitable only for industrial-grade use. The majority of natural diamonds come from central and southern Africa. Subject to frequent controversy, the mining and distribution of natural diamonds, has raised large concerns over the sale by African paramilitary groups. Article:A Diamond is a crystalline form of carbon. A diamonds hardness and high dispe… 4. Metaevolution - Evolution of Evolution Summary: Existing concept defines meta evolution as evolution of evolution since the big-bang ( i.e. the birth of universe), but I define metaevolution as the evolution of evolution (EoE) since the birth of life (on earth?). This means that all throughout life's history evolution has not remained same, it itself changes with time to time. Each changes the environment in his own way and thus affecting the process of evolution which applies to all organisms in that environment. It doesn't matter i… |
||||
